The trail begins with the Mittagsbrüche nature reserve, a large wetland meadow complex adjoining small arable fields. The comparatively small Wendequellgebiet nature reserve forms a kind of stepping stone on the way to the Wiehbruch nature reserve. The route continues past the Dörnschlade pilgrimage chapel into the Großmicketal nature reserve. The final section is the Biggetal nature reserve with its wide floodplain, where the river is still largely free to develop.